The Nature and Origin of Cosmic Rays Conventional wisdom holds that the majority of high energy atomic nuclei ("cosmic rays") that continually rain upon the Earth originate in galactic supernova shock waves. Despite many decades of intensive research on the subject, indirect evidence for this scenario has been only slowly accumulating. This is largely due to the difficulty in measuring the spectrum and mass composition of high-energy cosmic rays in the face of rapidly dwindling fluxes with energy. There is an expectation that the cosmic nuclei should have a progressively higher charge (and therefore mass), on average, with increasing energy, up to the astrophysical "knee" (spectral break) in the spectrum at around 3x1015 eV, but this has never been conclusively observed. Measurements of the details of the elemental particle spectra at Earth, particularly for some of the rare nuclear species produced by spallation reactions during interstellar transport, can also provide clues regarding the galactic propagation history of the cosmic rays. The CREAM (Cosmic Ray Energetics And Mass) experiment is a complex particle detector flown by high altitude balloon to directly measure the charge and energy of the cosmic rays at energies near the spectral knee. It flew successfully in Antarctica in Dec 04 / Jan 05 for a record-breaking 42 days, and again in Dec 05 / Jan 06 for 28 more days. We will review the science and performance of the instrument in flight, and present preliminary results and discuss prospects for additional CREAM missions.